I tried to go back and find a comic that was a good jumping point, but that is hard when  a comic goes back many years.  This is the start of the current storyline, which is as good as any.

but-

I would like you to go to Octopus Pie if you haven’t yet, and read it.  Go back, back, and then move forward through the archives.  Meredith has just been blowing me away with her stellar writing and characterizations, lots of nuance and honesty and humour, and one of the only comics I read that nails some truths of being part of a current 20-something generation.  It’s a great comic, a really great comic.  Don’t you let me down, reader.